Hematopoiesis

Hematopoiesis.

Enormous numbers of adult blood cells are constantly regenerated throughout life from hematopoietic stem cells through a series of progenitor stages. Accessibility, robust functional assays, well-established prospective isolation, and successful clinical application made hematopoiesis the classical mammalian stem cell system. Most of the basic concepts of stem cell biology have been defined in ...

SnapShot: Hematopoiesis

Pre-treatment with rapamycin protects hematopoiesis against radiation injury

Background: Protection of hematopoietic system has become a primary goal in the development of novel medical countermeasures against ionization radiation and radiotherapy. This study was to explore the role of rapamycin in normal tissues against radiation. Materials and Methods: Mice were pretreated with rapamycin by i.p. every other day for five times before 5 Gy or 8.5 Gy γ-ray whole bo...

Hematopoiesis and Stem Cells

The low incidence of CFU-F significantly complicates the isolation of homogeneous populations of mouse bone marrow stromal cells (BMSCs), a common problem being contamination with hematopoietic cells. Taking advantage of burgeoning evidence demonstrating the perivascular location of stromal cell stem/ progenitors, we hypothesized that a potential reason for the low yield of mouse BMSCs is the f...

Hematopoiesis and Stem Cells

Nicholas A. Watkins,1 Arief Gusnanto,2 Bernard de Bono,3 Subhajyoti De,4 Diego Miranda-Saavedra,5 Debbie L. Hardie,6 Will G. J. Angenent,7 Antony P. Attwood,7 Peter D. Ellis,7 Wendy Erber,8 Nicola S. Foad,1 Stephen F. Garner,1 Clare M. Isacke,9 Jennifer Jolley,1 Kerstin Koch,1 Iain C. Macaulay,1 Sarah L. Morley,1 Augusto Rendon,1 Kate M. Rice,7 Niall Taylor,1 Daphne C. Thijssen-Timmer,10 Marloe...